APLF

Across TCGA patient cohorts, APLF mutation is significantly associated with the RNA expression of many other genes, with 1,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APLF-associated genes across cancer lineages are P2RY10BP, SMIM11P1, and MTND2P25. Each is linked with APLF in more than 1 cancer types. Because this analysis shows association rather than direction, both APLF-to-partner and partner-to-APLF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RY10BP grouped by APLF-low versus APLF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APLF→partner) and Y-score (partner→APLF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	P2RY10BP →	+0.038	+4.594	.001	.008	3	2
UCEC	SMIM11P1 →	+0.205	+2.247	.007	.008	3	2
READ	MTND2P25 →	+0.230	+6.257	<.001	.001	3	2
BRCA	NMNAT1P2 →	+0.037	+5.866	<.001	.001	3	2
LUAD	RNA5SP251 →	+0.491	+6.599	<.001	<.001	3	2
HNSC	MIR4797 →	+0.524	+4.867	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,257 associations by consensus.

P2RY10BP by APLF expression — SKCM

Explore this box plot interactively →