APLF

Across TCGA pan-cancer cohorts, APLF RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of APLF’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where APLF RNA is repressed in tumor relative to normal tissue. In most cancer types APLF is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where APLF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APLF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.424	<.001	8	view →
KIRC	Male	All	+0.291	<.001	8	view →
LIHC	Female	II,III,IV	+0.537	<.001	7	view →
KICH	Female	II,III,IV	−0.790	<.001	6	view →
BRCA	All	III,IV	−0.773	<.001	6	view →
COAD	All	All	+0.459	<.001	6	view →
LUSC	Male	All	+0.414	<.001	4	view →
CHOL	All	All	+1.091	<.001	3	view →
LUAD	All	All	+0.274	<.001	3	view →
PRAD	All	All	−0.394	<.001	2	view →
ESCA	Female	All	+0.583	.014	1	view →
KIRP	All	All	+0.338	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

APLF–THCA

Open the THCA breakdown →