APIP

Across TCGA patient cohorts, APIP mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APIP-associated genes across cancer lineages are RNA5SP204, CYP4F44P, and MTND2P25. Each is linked with APIP in more than 1 cancer types. Because this analysis shows association rather than direction, both APIP-to-partner and partner-to-APIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP204 grouped by APIP-low versus APIP-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APIP→partner) and Y-score (partner→APIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP204 →	+0.191	+7.930	<.001	.008	3	2
UCEC	CYP4F44P →	+0.125	+4.034	.002	.001	3	2
LUAD	MTND2P25 →	+0.039	+7.930	.001	.008	3	1
LUAD	RNU7-95P →	+0.748	+7.930	<.001	.008	3	1
LUAD	LINC02379 →	+0.084	+7.930	<.001	.008	3	1
LUAD	HNRNPRP2 →	+0.034	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

RNA5SP204 by APIP expression — LUAD

Explore this box plot interactively →