APIP

Across TCGA pan-cancer cohorts, APIP RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of APIP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where APIP RNA is repressed in tumor relative to normal tissue. In most cancer types APIP is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LIHC, and LUAD are the cancer types where APIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.609	<.001	10	view →
LIHC	Male	II,III,IV	+1.305	<.001	9	view →
LUAD	Female	III,IV	−0.901	<.001	9	view →
KIRP	Male	All	−0.676	<.001	6	view →
LUSC	Male	All	−0.593	<.001	6	view →
KIRC	Male	II,III,IV	−0.517	<.001	6	view →
CHOL	All	All	+1.167	<.001	5	view →
KICH	All	All	−0.669	.001	4	view →
BRCA	All	IV	−0.660	.031	4	view →
STAD	All	II,III,IV	+0.330	.010	4	view →
READ	All	III,IV	+0.954	.014	2	view →
BLCA	Male	IV	−0.547	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

APIP–THCA

Open the THCA breakdown →