APH1B

Across TCGA cell cohorts, APH1B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible APH1B-associated genes across cancer lineages are OR51T1, OR2Z1, and ACTL9. Each is linked with APH1B in more than 1 cancer types. Because this analysis shows association rather than direction, both APH1B-to-partner and partner-to-APH1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51T1 grouped by APH1B-low versus APH1B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APH1B→partner) and Y-score (partner→APH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR51T1 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR2Z1 →	+0.056	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	ACTL9 →	+0.220	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	ARMS2 →	+0.031	+4.867	<.001	.009	3	1
LARGE_INTESTINE	OR14K1 →	+0.081	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR2AJ1 →	+0.010	+3.684	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR51T1 by APH1B expression — BLOOD_Lymphoma

Explore this box plot interactively →