APH1B

Across TCGA pan-cancer cohorts, APH1B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of APH1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where APH1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APH1B is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

HNSC, LUAD, and KIRP are the cancer types where APH1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APH1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.797	<.001	11	view →
LUAD	Female	III,IV	−1.387	<.001	9	view →
KIRP	All	III,IV	−1.208	<.001	9	view →
LUSC	Female	II,III,IV	−1.292	<.001	8	view →
UCEC	All	All	−1.615	<.001	6	view →
KIRC	All	II,III,IV	−0.466	<.001	6	view →
LIHC	Female	II,III,IV	+0.984	<.001	5	view →
BRCA	Female	All	−0.354	<.001	4	view →
CHOL	Female	All	+2.733	<.001	3	view →
THCA	Male	II,III,IV	−0.396	.014	3	view →
COAD	All	II,III,IV	+0.360	.019	3	view →
READ	All	III,IV	−0.705	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

APH1B–HNSC

Open the HNSC breakdown →