APCS

Across TCGA patient cohorts, APCS mutation is significantly associated with the RNA expression of many other genes, with 343 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible APCS-associated genes across cancer lineages are KRTAP19-5, OR6J1, and RNU6-42P. Each is linked with APCS in more than 2 cancer types. Because this analysis shows association rather than direction, both APCS-to-partner and partner-to-APCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-5 grouped by APCS-low versus APCS-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APCS→partner) and Y-score (partner→APCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KRTAP19-5 →	+0.158	+3.575	<.001	.003	3	3
HNSC	OR6J1 →	+0.107	+4.245	<.001	.008	3	2
UCEC	RNU6-42P →	+0.731	+2.964	.002	.004	3	2
UCEC	RN7SKP181 →	+0.123	+3.133	.001	.002	3	2
LUAD	KRTAP6-1 →	+0.046	+4.108	<.001	.007	3	2
LUAD	RNU6-1106P →	+0.155	+5.342	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 343 associations by consensus.

KRTAP19-5 by APCS expression — LUAD

Explore this box plot interactively →