APCS

Across TCGA pan-cancer cohorts, APCS RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of APCS’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where APCS RNA is repressed in tumor relative to normal tissue. In most cancer types APCS is over-expressed in tumor, although a few such as LIHC and KICH show the opposite, repressed pattern.

LIHC, KICH, and UCEC are the cancer types where APCS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APCS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	−2.493	<.001	7	view →
KICH	All	All	−1.525	.001	5	view →
UCEC	All	II,III,IV	−0.096	.024	4	view →
CHOL	All	All	−2.151	.001	2	view →
LUAD	All	All	+0.038	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

APCS–LIHC

Open the LIHC breakdown →