APCS

Across TCGA cell cohorts, APCS mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APCS-associated genes across cancer lineages are ODF4, NCR2, and OR1L1. Each is linked with APCS in more than 1 cancer types. Because this analysis shows association rather than direction, both APCS-to-partner and partner-to-APCS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF4 grouped by APCS-low versus APCS-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APCS→partner) and Y-score (partner→APCS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ODF4 →	+0.031	+4.977	<.001	.007	3	1
SKIN	NCR2 →	+0.020	+6.022	<.001	.001	3	1
LUNG_SCLC	OR1L1 →	+0.052	+5.029	<.001	.006	3	1
LUNG_SCLC	CLEC2A →	+0.129	+5.029	<.001	.006	3	1
LUNG_SCLC	OR11G2 →	+0.030	+5.643	<.001	.002	3	1
LARGE_INTESTINE	TEX47 →	+0.032	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ODF4 by APCS expression — SKIN

Explore this box plot interactively →