AP5S1

Across TCGA patient cohorts, AP5S1 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP5S1-associated genes across cancer lineages are LINC01957, RPS4XP21, and RNU6-502P. Each is linked with AP5S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP5S1-to-partner and partner-to-AP5S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01957 grouped by AP5S1-low versus AP5S1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5S1→partner) and Y-score (partner→AP5S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01957 →	+0.034	+7.930	<.001	.008	3	2
UCEC	RPS4XP21 →	+0.262	+3.785	.001	.002	3	1
UCEC	RNU6-502P →	+0.359	+4.123	<.001	.001	3	1
UCEC	H2AC9P →	+0.944	+3.691	<.001	.002	3	1
UCEC	CALM1P1 →	+0.363	+4.166	<.001	<.001	3	1
UCEC	PINCR →	+0.567	+3.086	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

LINC01957 by AP5S1 expression — LUAD

Explore this box plot interactively →