Across TCGA patient cohorts, AP2A1 mutation is significantly associated with the RNA expression of many other genes, with 4,912 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP2A1-associated genes across cancer lineages are CEP152, TRNAU1AP, and RCC1. Each is linked with AP2A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AP2A1-to-partner and partner-to-AP2A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2A1→partner) and Y-score (partner→AP2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEP152 →	+0.308	+1.668	.007	.003	3	3
COAD	TRNAU1AP →	+0.381	+3.240	.005	.008	3	3
UCEC	RCC1 →	+0.490	+4.010	<.001	<.001	3	3
KIRP	OFD1P4Y →	+0.046	+7.544	<.001	<.001	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
CESC	SNORD116-8 →	+0.346	+4.201	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,912 associations by consensus.

Exploration

AP2A1 survival (RNA) · tumor vs normal (RNA) · all AP2A1 data types