ANXA2R

Across TCGA cell cohorts, ANXA2R mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANXA2R-associated genes across cancer lineages are DEFA4, TMCO5A, and TBC1D21. Each is linked with ANXA2R in more than 1 cancer types. Because this analysis shows association rather than direction, both ANXA2R-to-partner and partner-to-ANXA2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by ANXA2R-low versus ANXA2R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANXA2R→partner) and Y-score (partner→ANXA2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

DEFA4 by ANXA2R expression — LARGE_INTESTINE

Explore this box plot interactively →