ANXA2R

Across TCGA pan-cancer cohorts, ANXA2R RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ANXA2R data layer compared with 4 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ANXA2R RNA is associated with better overall survival. In most high-consensus cancer types, elevated ANXA2R expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, ACC, and LGG are the cancer types where ANXA2R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.827	0.718	<.001	63	view →
ACC	OS	Median	All	0.444	0.781	.001	60	view →
LGG	DFS	Median	All	0.638	0.837	<.001	54	view →
KIRP	DFS	Median	II,III,IV	0.261	0.818	.006	46	view →
CESC	OS	Quartile	All	0.914	0.772	.005	34	view →
THYM	OS	Median	All	1.000	0.654	.005	21	view →
LIHC	OS	Median	All	0.465	0.681	.005	18	view →
MESO	OS	Tertile	II,III,IV	0.205	0.466	.011	18	view →
KIRC	DFS	Quartile	IV	0.365	0.731	.008	14	view →
HNSC	OS	Quartile	III,IV	0.531	0.280	.028	8	view →
BLCA	DFS	Tertile	IV	0.141	0.375	.015	7	view →
UVM	OS	Tertile	III,IV	0.346	1.000	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ANXA2R–SKCM (OS)

Open the SKCM breakdown →