ANXA2R

Across TCGA pan-cancer cohorts, ANXA2R RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ANXA2R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ANXA2R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANXA2R is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where ANXA2R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANXA2R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.540	<.001	11	view →
LIHC	Female	II,III,IV	+1.026	<.001	8	view →
HNSC	Male	All	+0.666	<.001	8	view →
KICH	All	All	−0.817	<.001	7	view →
STAD	All	II,III,IV	+0.753	<.001	7	view →
BRCA	All	III,IV	−0.441	<.001	6	view →
LUAD	All	All	+0.456	<.001	5	view →
ESCA	All	All	+0.770	<.001	4	view →
KIRP	All	All	+0.440	.015	3	view →
CHOL	All	All	+1.182	<.001	2	view →
LUSC	Male	III,IV	−0.972	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ANXA2R–KIRC

Open the KIRC breakdown →