ANO6

Across TCGA cell cohorts, ANO6 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANO6-associated genes across cancer lineages are OR1L3, RETN, and CHIT1. Each is linked with ANO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANO6-to-partner and partner-to-ANO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by ANO6-low versus ANO6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO6→partner) and Y-score (partner→ANO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	2
LUNG_NSCLC_LUAD	RETN →	+0.089	+3.628	<.001	.002	3	1
LUNG_NSCLC_LUAD	CHIT1 →	+0.081	+3.518	<.001	.008	3	1
STOMACH	MYH2 →	+0.038	+4.129	<.001	.007	3	1
STOMACH	OR14K1 →	+0.150	+4.285	<.001	.007	3	1
STOMACH	TGM7 →	+0.022	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR1L3 by ANO6 expression — SKIN

Explore this box plot interactively →