ANO6

Across TCGA pan-cancer cohorts, ANO6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ANO6 data layer compared with 5 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ANO6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANO6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

CESC, UVM, and KIRC are the cancer types where ANO6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.764	0.883	<.001	100	view →
UVM	DFS	Tertile	All	0.299	0.852	<.001	88	view →
KIRC	DFS	Median	All	0.732	0.507	<.001	82	view →
MESO	OS	Tertile	III,IV	0.248	0.529	.001	81	view →
HNSC	OS	Tertile	All	0.590	0.804	.001	53	view →
LGG	OS	Median	All	0.385	0.526	<.001	52	view →
PAAD	DFS	Quartile	All	0.187	0.435	.002	39	view →
BLCA	DFS	Tertile	All	0.159	0.586	.001	28	view →
LUSC	OS	Median	All	0.324	0.476	.004	26	view →
OV	OS	Median	III,IV	0.639	0.720	.008	24	view →
STAD	OS	Tertile	All	0.383	0.692	.008	22	view →
SCLC	OS	Quartile	II,III,IV	0.719	0.177	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ANO6–CESC (DFS)

Open the CESC breakdown →