ANO2

Across TCGA cell cohorts, ANO2 mutation is significantly associated with the RNA expression of many other genes, with 438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANO2-associated genes across cancer lineages are OR56A5, FTHL17, and RCHY1. Each is linked with ANO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANO2-to-partner and partner-to-ANO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A5 grouped by ANO2-low versus ANO2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO2→partner) and Y-score (partner→ANO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR56A5 →	+0.030	+5.357	<.001	.001	3	2
LARGE_INTESTINE	FTHL17 →	+0.032	+3.000	<.001	.003	3	2
LARGE_INTESTINE	RCHY1 →	+0.781	+3.237	.001	.003	3	2
LARGE_INTESTINE	IRX2 →	+1.408	+3.064	<.001	.009	3	2
SOFT_TISSUE	WFDC10A →	+0.071	+5.369	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR2AK2 →	+0.023	+5.362	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 438 associations by consensus.

OR56A5 by ANO2 expression — CNS

Explore this box plot interactively →