ANKRD34A

Across TCGA patient cohorts, ANKRD34A mutation is significantly associated with the RNA expression of many other genes, with 2,489 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD34A-associated genes across cancer lineages are MIR4450, SEPTIN7P5, and JOSD1. Each is linked with ANKRD34A in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD34A-to-partner and partner-to-ANKRD34A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4450 grouped by ANKRD34A-low versus ANKRD34A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD34A→partner) and Y-score (partner→ANKRD34A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4450 →	+0.555	+2.900	.001	.004	3	2
BLCA	SEPTIN7P5 →	+0.079	+6.048	<.001	<.001	3	2
UCEC	JOSD1 →	+0.478	+3.459	.001	.005	3	2
UCEC	RBFA →	+0.416	+3.354	.002	.005	3	2
UCEC	CTCF →	+0.530	+2.649	<.001	<.001	3	2
UCEC	NFKBIB →	+0.392	+3.584	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,489 associations by consensus.

MIR4450 by ANKRD34A expression — LUSC

Explore this box plot interactively →