ANK2

Across TCGA cell cohorts, ANK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,513 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANK2-associated GO terms across cancer lineages are Membrane depolarization during SA node cell action potential, SA node cell action potential, and SA node cell to atrial cardiac muscle cell signaling. Each is linked with ANK2 in more than 13 cancer types. Because this analysis shows association rather than direction, both ANK2-to-partner and partner-to-ANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane depolarization during SA node cell action potential grouped by ANK2-low versus ANK2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK2→partner) and Y-score (partner→ANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Membrane depolarization during SA node cell action potential →	+1.405	+1.956	<.001	<.001	3	14
LIVER	SA node cell action potential →	+1.481	+2.933	.001	<.001	3	12
LIVER	SA node cell to atrial cardiac muscle cell signaling →	+1.481	+2.933	.001	<.001	3	12
STOMACH	Cerebral cortex tangential migration →	+1.281	+1.836	<.001	<.001	3	12
URINARY_TRACT	Paranodal junction assembly →	-0.387	-1.651	<.001	<.001	3	11
STOMACH	Positive regulation of potassium ion import across plasma membrane →	-0.319	-2.065	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,513 associations by consensus.

Membrane depolarization during SA node cell action potential by ANK2 expression — LUNG_SCLC

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