ANK2

Across TCGA pan-cancer cohorts, ANK2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ANK2 data layer compared with 13 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ANK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ANK2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

UVM, BLCA, and LUSC are the cancer types where ANK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	III,IV	0.366	0.919	.002	61	view →
BLCA	OS	Tertile	II,III,IV	0.346	0.593	.003	59	view →
LUSC	DFS	Median	II,III,IV	0.274	0.532	<.001	45	view →
THCA	OS	Quartile	All	0.843	1.000	.001	39	view →
LUAD	OS	Quartile	II,III,IV	0.891	0.636	.006	29	view →
PAAD	DFS	Quartile	All	0.536	0.312	.009	28	view →
SARC	OS	Median	All	0.925	0.717	<.001	23	view →
KIRP	DFS	Quartile	All	0.866	0.985	.001	23	view →
UCEC	DFS	Tertile	II,III,IV	0.659	0.819	.009	22	view →
BRCA	DFS	Median	III,IV	0.935	0.817	.003	17	view →
ACC	OS	Quartile	II,III,IV	0.637	0.347	.005	12	view →
HNSC	DFS	Median	IV	0.706	0.574	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ANK2–UVM (OS)

Open the UVM breakdown →