ANK2

Across TCGA pan-cancer cohorts, ANK2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ANK2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ANK2 RNA is repressed in tumor relative to normal tissue. In most cancer types ANK2 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where ANK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.786	<.001	12	view →
KICH	Male	All	−4.363	<.001	11	view →
THCA	Male	II,III,IV	−2.757	<.001	11	view →
KIRC	Male	All	−2.417	<.001	11	view →
BLCA	Male	All	−2.412	<.001	11	view →
LUSC	Male	II,III,IV	−1.525	<.001	8	view →
HNSC	Male	All	−1.194	<.001	8	view →
KIRP	Male	All	−3.061	<.001	7	view →
UCEC	All	All	−2.269	<.001	6	view →
BRCA	All	III,IV	−1.756	<.001	6	view →
LUAD	Female	II,III,IV	−0.688	<.001	6	view →
STAD	All	All	−1.248	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ANK2–COAD

Open the COAD breakdown →