ANK2

Across TCGA cell cohorts, ANK2 mutation is significantly associated with the RNA expression of many other genes, with 1,842 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANK2-associated genes across cancer lineages are WHRN, DDHD1, and SEMA3G. Each is linked with ANK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANK2-to-partner and partner-to-ANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WHRN grouped by ANK2-low versus ANK2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK2→partner) and Y-score (partner→ANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	WHRN →	+0.914	+2.399	.005	.005	3	5
LARGE_INTESTINE	DDHD1 →	+0.622	+1.545	.001	.004	3	3
LARGE_INTESTINE	SEMA3G →	+0.661	+2.780	.001	<.001	3	3
LARGE_INTESTINE	UBE3A →	+0.540	+3.541	<.001	<.001	3	3
LARGE_INTESTINE	CDC42BPB →	+0.547	+2.222	.005	.001	3	3
BLOOD_Lymphoma	UFSP2 →	+0.540	+2.658	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,842 associations by consensus.

WHRN by ANK2 expression — OVARY

Explore this box plot interactively →