ANK2

Across TCGA cell cohorts, ANK2 mutation is significantly associated with the mutation status of many other genes, with 5,366 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANK2-associated genes across cancer lineages are FSIP2, PLXNA1, and KMT2A. Each is linked with ANK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ANK2-to-partner and partner-to-ANK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSIP2 grouped by ANK2-low versus ANK2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK2→partner) and Y-score (partner→ANK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FSIP2 →	+2.807	+2.662	.002	.002	1	6
LARGE_INTESTINE	PLXNA1 →	+2.173	+1.578	<.001	<.001	1	6
OVARY	KMT2A →	+2.994	+1.962	.006	.006	1	6
BLOOD_Leukemia	ZFHX4 →	+1.613	+1.895	<.001	<.001	1	5
LARGE_INTESTINE	EPHA5 →	+3.325	+2.310	<.001	<.001	1	5
SKIN	CACNA1B →	+2.284	+2.013	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,366 associations by consensus.

FSIP2 by ANK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →