ANGPT4

Across TCGA cell cohorts, ANGPT4 mutation is significantly associated with the mutation status of many other genes, with 2,488 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANGPT4-associated genes across cancer lineages are MYH9, SCML2, and HRC. Each is linked with ANGPT4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANGPT4-to-partner and partner-to-ANGPT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH9 grouped by ANGPT4-low versus ANGPT4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT4→partner) and Y-score (partner→ANGPT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MYH9 →	+3.329	+4.562	.003	.003	1	3
CNS	SCML2 →	+5.277	+4.459	.005	.005	1	3
CNS	HRC →	+5.277	+4.459	.005	.005	1	3
SKIN	SLC11A2 →	+4.824	+5.392	.004	.004	1	3
SKIN	KNG1 →	+4.239	+5.053	.007	.007	1	3
BLOOD_Leukemia	STRIP2 →	+4.635	+4.145	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,488 associations by consensus.

MYH9 by ANGPT4 expression — LUNG_SCLC

Explore this box plot interactively →