ANGPT4

Across TCGA pan-cancer cohorts, ANGPT4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ANGPT4 data layer compared with 9 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ANGPT4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ANGPT4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

OV, KIRC, and UCS are the cancer types where ANGPT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Tertile	All	0.285	0.383	.003	54	view →
KIRC	DFS	Quartile	All	0.712	0.546	.003	48	view →
UCS	DFS	Median	IV	0.367	0.952	.001	40	view →
LIHC	OS	Median	All	0.758	0.613	.001	32	view →
STAD	OS	Median	All	0.392	0.661	.001	31	view →
UCEC	DFS	Quartile	All	0.774	0.928	<.001	30	view →
MESO	DFS	Quartile	III,IV	0.586	0.313	.008	27	view →
BRCA	OS	Tertile	III,IV	0.913	0.768	.003	26	view →
KICH	DFS	Median	All	0.947	0.709	.009	20	view →
KIRP	OS	Quartile	All	0.849	0.952	.009	14	view →
THCA	DFS	Quartile	IV	1.000	0.736	.006	13	view →
UVM	DFS	Median	All	0.369	0.657	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ANGPT4–OV (OS)

Open the OV breakdown →