AMT

Across TCGA patient cohorts, AMT mutation is significantly associated with the RNA expression of many other genes, with 1,268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMT-associated genes across cancer lineages are RNU6-715P, MIRLET7A2, and MIR6075. Each is linked with AMT in more than 1 cancer types. Because this analysis shows association rather than direction, both AMT-to-partner and partner-to-AMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-715P grouped by AMT-low versus AMT-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMT→partner) and Y-score (partner→AMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-715P →	+0.295	+6.040	<.001	.001	3	2
HNSC	MIRLET7A2 →	+0.667	+5.912	<.001	.002	3	2
UCEC	MIR6075 →	+0.259	+2.638	.005	.003	3	2
SKCM	SNORD31B →	+0.518	+6.643	<.001	<.001	3	2
BLCA	MAGEB4 →	+0.181	+4.883	<.001	.002	3	1
BLCA	RNA5SP48 →	+0.257	+4.497	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,268 associations by consensus.

RNU6-715P by AMT expression — BLCA

Explore this box plot interactively →