AMT

Across TCGA patient cohorts, AMT mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMT-associated genes across cancer lineages are PCNA, ATM, and Caspase-7-cleavedD198. Each is linked with AMT in more than 1 cancer types. Because this analysis shows association rather than direction, both AMT-to-partner and partner-to-AMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by AMT-low versus AMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMT→partner) and Y-score (partner→AMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.361	+2.321	<.001	.035	3	2
UCEC	ATM →	-0.879	-3.459	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.711	+2.827	.017	.035	3	2
UCEC	FOXO3a_pS318_S321 →	-0.123	-2.990	.049	.036	3	1
UCEC	INPP4B →	-0.336	-3.169	.038	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-2.308	.014	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PCNA by AMT expression — UCEC

Explore this box plot interactively →