AMIGO2

Across TCGA cell cohorts, AMIGO2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible AMIGO2-associated genes across cancer lineages are DEFB134, MYH4, and VN1R4. Each is linked with AMIGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMIGO2-to-partner and partner-to-AMIGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB134 grouped by AMIGO2-low versus AMIGO2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMIGO2→partner) and Y-score (partner→AMIGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DEFB134 →	+0.176	+4.169	<.001	.008	3	2
LUNG_NSCLC_LUAD	MYH4 →	+0.006	+5.662	.003	.002	3	2
CNS	VN1R4 →	+0.073	+4.754	<.001	.005	3	1
SKIN	OR2A4 →	+0.161	+3.242	<.001	.003	3	1
SKIN	TPSD1 →	+0.240	+3.426	.001	.007	3	1
LUNG_NSCLC_LUAD	DEFA6 →	+0.167	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

DEFB134 by AMIGO2 expression — CNS

Explore this box plot interactively →