AMIGO2

Across TCGA pan-cancer cohorts, AMIGO2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of AMIGO2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AMIGO2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AMIGO2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where AMIGO2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMIGO2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.836	<.001	12	view →
THCA	Male	IV	+2.336	<.001	11	view →
KIRC	All	III,IV	−0.956	<.001	11	view →
KIRP	Female	All	−1.931	<.001	9	view →
UCEC	All	All	−2.513	<.001	8	view →
BLCA	All	IV	+1.972	.001	8	view →
LUSC	All	All	−0.730	<.001	7	view →
BRCA	Female	All	−1.412	<.001	4	view →
ESCA	Male	All	+1.982	.019	2	view →
PAAD	All	All	+1.607	.036	2	view →
KICH	Female	All	−1.438	.012	2	view →
STAD	Male	II,III,IV	+1.405	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

AMIGO2–HNSC

Open the HNSC breakdown →