AMHR2

Across TCGA patient cohorts, AMHR2 mutation is significantly associated with the RNA expression of many other genes, with 1,769 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMHR2-associated genes across cancer lineages are ATP5MC1, MED27, and URM1. Each is linked with AMHR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMHR2-to-partner and partner-to-AMHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5MC1 grouped by AMHR2-low versus AMHR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMHR2→partner) and Y-score (partner→AMHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5MC1 →	+0.432	+2.928	.001	<.001	3	2
UCEC	MED27 →	+0.301	+1.871	.008	.002	3	2
UCEC	URM1 →	+0.382	+2.169	<.001	<.001	3	2
UCEC	UBXN6 →	+0.350	+2.369	.001	.003	3	2
UCEC	NUDC →	+0.422	+2.158	.001	<.001	3	2
UCEC	LONP1 →	+0.651	+2.534	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,769 associations by consensus.

ATP5MC1 by AMHR2 expression — UCEC

Explore this box plot interactively →