AMHR2

Across TCGA patient cohorts, AMHR2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMHR2-associated genes across cancer lineages are 14-3-3_zeta, Gab2, and N-Ras. Each is linked with AMHR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMHR2-to-partner and partner-to-AMHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_zeta grouped by AMHR2-low versus AMHR2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMHR2→partner) and Y-score (partner→AMHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_zeta →	+0.205	+3.000	.027	.035	3	3
UCEC	Gab2 →	+0.305	+3.321	.017	.010	3	2
UCEC	N-Ras →	-0.116	-1.571	.006	.019	3	2
UCEC	P-Cadherin →	-0.132	-1.690	.010	.042	3	2
UCEC	PCNA →	+0.272	+2.807	<.001	.002	3	2
UCEC	PEA-15_pS116 →	+0.356	+1.584	.004	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

14-3-3_zeta by AMHR2 expression — SKCM

Explore this box plot interactively →