AMHR2

Across TCGA cell cohorts, AMHR2 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMHR2-associated genes across cancer lineages are OR52E2, TPPP2, and CDR1. Each is linked with AMHR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMHR2-to-partner and partner-to-AMHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E2 grouped by AMHR2-low versus AMHR2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMHR2→partner) and Y-score (partner→AMHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR52E2 →	+0.037	+3.930	.001	.003	3	1
SKIN	TPPP2 →	+0.068	+4.217	<.001	.001	3	1
SKIN	CDR1 →	+0.207	+3.920	.001	.005	3	1
LARGE_INTESTINE	CBY1 →	+0.776	+3.307	<.001	.003	3	1
LARGE_INTESTINE	MIOX →	+0.264	+3.087	.003	.006	3	1
LARGE_INTESTINE	GBE1 →	+0.704	+3.212	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

OR52E2 by AMHR2 expression — SKIN

Explore this box plot interactively →