AMH

Across TCGA patient cohorts, AMH mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMH-associated genes across cancer lineages are CSN2, OR4E2, and OR10G9. Each is linked with AMH in more than 1 cancer types. Because this analysis shows association rather than direction, both AMH-to-partner and partner-to-AMH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by AMH-low versus AMH-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMH→partner) and Y-score (partner→AMH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CSN2 →	+0.075	+5.189	<.001	.006	3	1
SCLC	OR4E2 →	+0.137	+6.228	<.001	.001	3	1
SCLC	OR10G9 →	+0.091	+6.228	<.001	.001	3	1
UCEC	RNU6-739P →	+0.511	+4.852	<.001	.006	3	1
UCEC	RSL24D1P4 →	+0.129	+4.551	.003	.009	3	1
UCEC	RNU6-1054P →	+0.582	+4.661	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

CSN2 by AMH expression — SCLC

Explore this box plot interactively →