Across TCGA patient cohorts, AMELY RNA expression is significantly associated with the go_rna of many other GO terms, with 5,125 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible AMELY-associated GO terms across cancer lineages are Sequestering of actin monomers, Virion assembly, and L-serine biosynthetic process. Each is linked with AMELY in more than 5 cancer types. Because this analysis shows association rather than direction, both AMELY-to-partner and partner-to-AMELY results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMELY→partner) and Y-score (partner→AMELY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Sequestering of actin monomers →	-0.069	-0.334	<.001	<.001	3	6
STAD	Virion assembly →	+0.063	+0.033	<.001	.003	3	6
STAD	L-serine biosynthetic process →	+0.066	+0.045	<.001	<.001	3	6
ESCA	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.065	+0.072	<.001	.001	3	6
STAD	Cellular ketone metabolic process →	+0.049	+0.069	<.001	<.001	2	6
STAD	Oligodendrocyte differentiation →	+0.060	+0.063	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,125 associations by consensus.

Exploration

AMELY survival (RNA) · tumor vs normal (RNA) · all AMELY data types