AMELY

Across TCGA pan-cancer cohorts, AMELY RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of AMELY’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AMELY RNA is repressed in tumor relative to normal tissue. In most cancer types AMELY is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where AMELY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMELY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−0.643	<.001	8	view →
KIRC	Male	II,III,IV	−0.382	<.001	8	view →
KIRP	Male	All	−0.337	<.001	8	view →
THCA	Male	III,IV	−1.511	<.001	6	view →
ESCA	All	II,III,IV	−0.290	.040	2	view →
PRAD	All	All	+0.229	.008	2	view →
LUSC	Male	All	+0.056	.049	1	view →
STAD	Male	All	−0.023	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

AMELY–KICH

Open the KICH breakdown →