AMELY

Across TCGA patient cohorts, AMELY protein abundance is significantly associated with the RNA expression of many other genes, with 14,638 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AMELY-associated genes across cancer lineages are PTGDS, CBX7, and GINS2. Each is linked with AMELY in more than 6 cancer types. Because this analysis shows association rather than direction, both AMELY-to-partner and partner-to-AMELY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AMELY versus PTGDS in GBM, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMELY→partner) and Y-score (partner→AMELY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTGDS →	-1.034	-0.285	.001	<.001	3	7
BRCA	CBX7 →	-0.668	-0.326	<.001	.002	3	7
LUAD	GINS2 →	+0.766	+0.382	.003	.001	3	7
GBM	FANCA →	+0.709	+0.379	<.001	<.001	3	7
UCEC	HMGA1 →	+0.837	+0.321	<.001	<.001	3	7
BRCA	ECM2 →	-1.275	-0.501	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,638 associations by consensus.

AMELY vs PTGDS — GBM

Explore this scatter interactively →