AMELY

Across TCGA patient cohorts, AMELY mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible AMELY-associated genes across cancer lineages are RNU6-600P, RNU6-1126P, and RN7SKP213. Each is linked with AMELY in more than 1 cancer types. Because this analysis shows association rather than direction, both AMELY-to-partner and partner-to-AMELY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-600P grouped by AMELY-low versus AMELY-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMELY→partner) and Y-score (partner→AMELY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-600P →	+0.358	+5.343	<.001	.006	3	1
LUAD	RNU6-1126P →	+0.476	+6.444	<.001	.001	3	1
LUAD	RN7SKP213 →	+0.206	+5.410	<.001	.005	3	1
LUAD	STSP1 →	+0.115	+5.554	<.001	.004	3	1
LUAD	RNU7-136P →	+0.660	+5.554	<.001	.004	3	1
LUAD	RNU7-56P →	+0.532	+5.798	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

RNU6-600P by AMELY expression — LUAD

Explore this box plot interactively →