AMELY

Across TCGA cell cohorts, AMELY RNA expression is significantly associated with the mutation status of many other genes, with 124 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMELY-associated genes across cancer lineages are ABCA7, ADCY2, and ACSBG1. Each is linked with AMELY in more than 1 cancer types. Because this analysis shows association rather than direction, both AMELY-to-partner and partner-to-AMELY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCA7 grouped by AMELY-low versus AMELY-high in BLOOD_Myeloma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMELY→partner) and Y-score (partner→AMELY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ABCA7 →	+3.169	+0.071	.004	.001	3	2
OESOPHAGUS	ADCY2 →	+3.273	+0.036	.004	<.001	3	2
SKIN	ACSBG1 →	+4.415	+0.027	.007	<.001	3	2
BLOOD_Myeloma	NBEA →	+3.169	+0.071	.004	.001	3	1
OESOPHAGUS	LRRFIP1 →	+4.857	+0.055	<.001	<.001	3	1
OESOPHAGUS	DOP1B →	+4.857	+0.055	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 124 associations by consensus.

ABCA7 by AMELY expression — BLOOD_Myeloma

Explore this box plot interactively →