ALS2CL

Across TCGA patient cohorts, ALS2CL protein abundance is significantly associated with the RNA expression of many other genes, with 6,658 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ALS2CL-associated genes across cancer lineages are ZKSCAN8, TNRC6C, and PTK6. Each is linked with ALS2CL in more than 3 cancer types. Because this analysis shows association rather than direction, both ALS2CL-to-partner and partner-to-ALS2CL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALS2CL versus ZKSCAN8 in HNSC, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALS2CL→partner) and Y-score (partner→ALS2CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZKSCAN8 →	-0.673	-0.289	<.001	.004	3	4
LSCC	TNRC6C →	-0.713	-0.394	<.001	<.001	3	4
LSCC	PTK6 →	+0.998	+0.281	<.001	<.001	3	3
LSCC	SCML2 →	-1.375	-0.356	<.001	<.001	3	3
HNSC	PLIN3 →	+0.918	+0.409	.002	<.001	3	3
HNSC	CAV1 →	+1.209	+0.326	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,658 associations by consensus.

ALS2CL vs ZKSCAN8 — HNSC

Explore this scatter interactively →