ALS2CL

Across TCGA pan-cancer cohorts, ALS2CL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ALS2CL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ALS2CL RNA is repressed in tumor relative to normal tissue. In most cancer types ALS2CL is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where ALS2CL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALS2CL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−2.523	<.001	12	view →
KIRP	All	II,III,IV	−1.535	<.001	9	view →
HNSC	All	II,III,IV	−0.645	.003	9	view →
LUAD	Male	All	−1.426	<.001	8	view →
COAD	All	All	+0.681	<.001	8	view →
LIHC	Female	All	+1.069	<.001	7	view →
THCA	All	All	+0.567	<.001	7	view →
LUSC	Female	II,III,IV	−2.382	<.001	6	view →
BRCA	All	All	−1.052	<.001	6	view →
CHOL	Female	All	+2.083	<.001	5	view →
PAAD	All	All	+1.830	.045	2	view →
PRAD	All	All	−0.859	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ALS2CL–KIRC

Open the KIRC breakdown →