ALS2CL

Across TCGA pan-cancer cohorts, ALS2CL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ALS2CL data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ALS2CL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALS2CL expression acts as an unfavorable survival marker, although some lineages such as ESCA and SARC show a favorable association.

KIRC, ESCA, and SARC are the cancer types where ALS2CL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.424	0.620	<.001	102	view →
ESCA	OS	Median	III,IV	0.745	0.394	<.001	65	view →
SARC	OS	Median	All	0.823	0.665	<.001	36	view →
BLCA	OS	Quartile	II,III,IV	0.695	0.537	.009	32	view →
OV	OS	Median	IV	0.621	0.874	.011	32	view →
LGG	DFS	Tertile	All	0.373	0.471	.002	30	view →
STAD	OS	Median	II,III,IV	0.819	0.601	.007	26	view →
UVM	DFS	Quartile	III,IV	0.184	0.685	.005	23	view →
PRAD	DFS	Tertile	All	0.819	0.930	<.001	22	view →
MESO	OS	Median	II,III,IV	0.362	0.684	.024	21	view →
PAAD	DFS	Tertile	All	0.224	0.463	.012	16	view →
COAD	OS	Quartile	All	0.421	0.796	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ALS2CL–KIRC (DFS)

Open the KIRC breakdown →