ALS2CL

Across TCGA patient cohorts, ALS2CL mutation is significantly associated with the RNA expression of many other genes, with 1,381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALS2CL-associated genes across cancer lineages are GAS2L1, CMC4, and MAGEB6. Each is linked with ALS2CL in more than 2 cancer types. Because this analysis shows association rather than direction, both ALS2CL-to-partner and partner-to-ALS2CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAS2L1 grouped by ALS2CL-low versus ALS2CL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALS2CL→partner) and Y-score (partner→ALS2CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAS2L1 →	+0.409	+2.849	.001	.001	3	3
LUSC	CMC4 →	+0.018	+5.906	.005	.001	3	3
LUAD	MAGEB6 →	+0.309	+3.027	<.001	.009	3	2
CESC	PRAMEF14 →	+0.119	+5.254	<.001	<.001	3	2
CESC	TRIM51GP →	+0.631	+4.786	<.001	.001	3	2
CESC	LINC00351 →	+0.118	+4.786	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,381 associations by consensus.

GAS2L1 by ALS2CL expression — UCEC

Explore this box plot interactively →