ALS2CL

Across TCGA cell cohorts, ALS2CL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALS2CL-associated GO terms across cancer lineages are Negative regulation of supramolecular fiber organization, Mammary gland morphogenesis, and Protein localization to plasma membrane. Each is linked with ALS2CL in more than 12 cancer types. Because this analysis shows association rather than direction, both ALS2CL-to-partner and partner-to-ALS2CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of supramolecular fiber organization grouped by ALS2CL-low versus ALS2CL-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALS2CL→partner) and Y-score (partner→ALS2CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of supramolecular fiber organization →	+0.080	+1.720	<.001	.001	3	13
OVARY	Mammary gland morphogenesis →	+0.207	+1.948	<.001	.002	3	13
BONE	Protein localization to plasma membrane →	+0.092	+0.890	<.001	.008	3	13
URINARY_TRACT	Negative regulation of actin filament polymerization →	+0.177	+3.068	<.001	<.001	3	13
OESOPHAGUS	Cell-substrate adhesion →	+0.131	+2.118	.004	.006	3	13
OVARY	Plasma membrane organization →	+0.121	+2.110	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

Negative regulation of supramolecular fiber organization by ALS2CL expression — URINARY_TRACT

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