ALS2CL

Across TCGA cell cohorts, ALS2CL mutation is significantly associated with the RNA expression of many other genes, with 135 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALS2CL-associated genes across cancer lineages are FAM160A1, UCMA, and VWC2L. Each is linked with ALS2CL in more than 1 cancer types. Because this analysis shows association rather than direction, both ALS2CL-to-partner and partner-to-ALS2CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM160A1 grouped by ALS2CL-low versus ALS2CL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALS2CL→partner) and Y-score (partner→ALS2CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM160A1 →	+0.284	+3.684	<.001	.005	3	2
BLOOD_Leukemia	UCMA →	+0.058	+4.189	<.001	<.001	3	2
LARGE_INTESTINE	VWC2L →	+0.006	+2.760	.003	.003	3	2
LUNG_NSCLC_LUAD	SCGB1C1 →	+0.055	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	C7orf77 →	+0.054	+4.662	<.001	.005	3	1
OVARY	H1-8 →	+0.059	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 135 associations by consensus.

FAM160A1 by ALS2CL expression — BLOOD_Leukemia

Explore this box plot interactively →