ALPG

Across TCGA cell cohorts, ALPG mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALPG-associated genes across cancer lineages are AMY2A, TRIM49D2, and OR2B3. Each is linked with ALPG in more than 1 cancer types. Because this analysis shows association rather than direction, both ALPG-to-partner and partner-to-ALPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMY2A grouped by ALPG-low versus ALPG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALPG→partner) and Y-score (partner→ALPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AMY2A →	+0.059	+3.930	<.001	.003	3	2
STOMACH	TRIM49D2 →	+0.040	+5.285	<.001	.003	3	1
BREAST	OR2B3 →	+0.015	+4.781	<.001	.003	3	1
OVARY	TAS2R39 →	+0.028	+3.990	<.001	.003	3	1
LARGE_INTESTINE	SLC1A6 →	+0.454	+3.662	.003	.005	3	1
LARGE_INTESTINE	SUFU →	+0.734	+3.082	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

AMY2A by ALPG expression — SKIN

Explore this box plot interactively →