ALPG

Across TCGA pan-cancer cohorts, ALPG RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ALPG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ALPG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALPG is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

HNSC, STAD, and LUSC are the cancer types where ALPG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALPG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.317	.001	6	view →
STAD	Male	All	+2.179	<.001	5	view →
LUSC	Female	All	−1.286	<.001	5	view →
BLCA	All	All	+0.642	.015	5	view →
COAD	All	All	−0.618	.004	4	view →
BRCA	All	II,III,IV	+0.032	.031	4	view →
LUAD	Male	All	−0.819	<.001	3	view →
UCEC	All	All	+1.974	.005	2	view →
ESCA	Female	All	+0.593	<.001	1	view →
THCA	Male	All	−0.065	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ALPG–HNSC

Open the HNSC breakdown →