ALKBH4

Across TCGA patient cohorts, ALKBH4 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH4-associated genes across cancer lineages are CMP, lymphatic Endothelial cells, and NKT. Each is linked with ALKBH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH4-to-partner and partner-to-ALKBH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP grouped by ALKBH4-low versus ALKBH4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH4→partner) and Y-score (partner→ALKBH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CMP →	+0.023	+3.315	.015	.040	3	2
UCEC	lymphatic Endothelial cells →	-0.019	-2.968	.046	.036	3	1
UCEC	NKT →	-0.116	-3.435	.006	.005	3	1
UCEC	Sebocytes →	-0.023	-1.885	.021	.017	3	1
UCEC	Th2 cells →	+0.179	+1.708	.013	.026	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CMP by ALKBH4 expression — LUSC

Explore this box plot interactively →