ALKBH4

Across TCGA pan-cancer cohorts, ALKBH4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ALKBH4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ALKBH4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALKBH4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where ALKBH4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALKBH4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.853	<.001	12	view →
KIRC	Male	III,IV	+0.441	<.001	12	view →
LIHC	Female	II,III,IV	+1.125	<.001	9	view →
COAD	All	All	+0.360	<.001	9	view →
STAD	Male	II,III,IV	+0.840	<.001	8	view →
LUSC	Male	II,III,IV	+0.908	<.001	7	view →
LUAD	All	All	+0.408	<.001	7	view →
BLCA	All	All	+0.806	.001	6	view →
KIRP	All	IV	+0.730	.003	6	view →
CHOL	All	All	+1.691	<.001	5	view →
THCA	Male	II,III,IV	−0.444	.008	4	view →
BRCA	All	All	+0.204	.011	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ALKBH4–HNSC

Open the HNSC breakdown →