ALKBH4

Across TCGA pan-cancer cohorts, ALKBH4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ALKBH4 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ALKBH4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALKBH4 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SARC show a favorable association.

KICH, UVM, and LIHC are the cancer types where ALKBH4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	III,IV	0.172	1.000	<.001	101	view →
UVM	DFS	Median	II,III,IV	0.322	0.646	.001	72	view →
LIHC	DFS	Median	All	0.466	0.615	<.001	41	view →
COAD	OS	Median	II,III,IV	0.792	0.916	.004	40	view →
LGG	OS	Tertile	All	0.735	0.859	<.001	33	view →
OV	OS	Median	All	0.815	0.866	.014	22	view →
ESCA	DFS	Median	II,III,IV	1.000	0.303	.004	20	view →
ACC	DFS	Quartile	II,III,IV	0.278	0.682	.014	13	view →
SARC	DFS	Quartile	All	0.435	0.166	.005	13	view →
CHOL	DFS	Tertile	III,IV	0.779	0.154	.024	12	view →
STAD	OS	Tertile	III,IV	0.605	0.393	.021	10	view →
KIRC	DFS	Quartile	All	0.704	0.451	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ALKBH4–KICH (DFS)

Open the KICH breakdown →