ALKBH4

Across TCGA cell cohorts, ALKBH4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,667 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ALKBH4-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Positive regulation of isotype switching to IgG isotypes, and Regulation of double-strand break repair via homologous recombination. Each is linked with ALKBH4 in more than 14 cancer types. Because this analysis shows association rather than direction, both ALKBH4-to-partner and partner-to-ALKBH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by ALKBH4-low versus ALKBH4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH4→partner) and Y-score (partner→ALKBH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.176	+0.751	<.001	<.001	3	15
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.162	+0.764	<.001	.005	3	14
BONE	Regulation of double-strand break repair via homologous recombination →	+0.145	+0.996	<.001	<.001	3	13
BONE	Positive regulation of DNA metabolic process →	+0.077	+0.710	<.001	<.001	3	13
BONE	Nuclear export →	+0.089	+0.774	<.001	<.001	3	12
PANCREAS	DNA replication checkpoint signaling →	+0.157	+0.442	<.001	.004	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,667 associations by consensus.

Pre-mRNA catabolic process by ALKBH4 expression — BONE

Explore this box plot interactively →